In the clinic, the patient had difficulty in speaking and hoarseness of in voice. The patient history was significant for 60 packs years of smoking. The patient also described a 20-pound weight loss over the last several months due to his dysphagia and odynophagia. Case ReportĪ 67-year-old Caucasian male presented to the internal medicine clinic with 2-month history of progressive hoarseness that has been affecting his ability to speak and dysphagia. The following is a case report of one such patient who presented to our institution with spindle cell (sarcomatoid) carcinoma of the larynx. Since a majority of these tumors are polypoid or pedunculated and tend to cause obstructive symptoms, these tumors are often detected at an early stage, removed by polypectomy during diagnosis, and tend to have a very good prognosis. Spindle cell carcinoma is considered to be a biphasic tumor that is composed of a squamous cell carcinoma (in situ or invasive) and spindle cell carcinoma with sarcomatous appearance. Squamous cell carcinoma is the most malignant carcinoma of the larynx, and spindle cell (sarcomatoid) tumor is considered a highly malignant variant of squamous cell carcinoma. Spindle cell (sarcomatoid) carcinoma of the larynx is a rare tumor and comprises 2% to 3% of all laryngeal cancers. His symptoms gradually improved, and he regained good control of his voice. The patient underwent direct laryngoscopy with excision of the malignant mass and received radiation therapy. We present a case of spindle cell carcinoma in a 67-year-old Caucasian male who presented with progressive hoarseness of his voice, dysphagia, odynophagia and a 20-pound weight loss. Most spindle cell tumors are polypoid and pedunculated they are often detected at an early stage, removed by polypectomy during diagnosis, and tend to have a very good prognosis. It is considered to be a biphasic tumor that is composed of a squamous cell carcinoma (in situ or invasive) and spindle cell carcinoma with sarcomatous appearance. In this instance, there may not be enough tissue available for the pathologist to make a final diagnosis and then the term spindle-cell neoplasm is used to provide a preliminary diagnosis that your doctors may use to start planning your care.Spindle cell carcinoma (SpCC) or sarcomatoid carcinoma is a highly malignant variant of squamous cell carcinoma which comprises 2% to 3% of all laryngeal cancers. Pathologists often use the term spindle-cell neoplasm when describing a small tissue sample, such as a biopsy. When do pathologists use the term spindle-cell neoplasm? Some other types of cancers such as squamous cell carcinoma and melanoma can also be made up entirely of spindle cells. Examples of sarcomas include malignant peripheral nerve sheath tumour, dermatofibrosarcoma protuberans, liposarcoma, osteosarcoma, leiomyosarcoma, angiosarcoma, synovial sarcoma, and undifferentiated pleomorphic sarcoma. Cancers in this group can start anywhere in the body. Most cancerous spindle cell neoplasms are part of a large group of cancers called sarcomas. What are some examples of cancerous spindle-cell neoplasms?
#Spindle cell carcinoma free
While all of these are non-cancerous, some (such as fibromatosis) can grow back after being surgically removed and routine follow-up with your doctor may be necessary to make sure you remain free of tumour. Examples include schwannoma, neurofibroma, solitary fibrous tumour, spindle-cell lipoma, leiomyoma, and fibromatosis. There are many different types of non-cancerous spindle-cell neoplasms. What are some examples of non-cancerous spindle-cell neoplasms? By examining the tissue under the microscope and performing additional tests, such as immunohistochemistry, fluorescence in situ hybridization (FISH), and next-generation sequencing (NGS), your pathologist will decide if the spindle cell neoplasm is benign or malignant (cancerous). There are many types of spindle-cell neoplasms that are benign (non-cancerous). Most malignant spindle-cell neoplasms are called sarcomas.Īre all spindle-cell neoplasms cancerous? Spindle-cell neoplasm is considered a general term because it includes many different types of benign (non-cancerous) and malignant (cancerous) growths. A spindle-cell neoplasm is a general term used to describe an abnormal growth (a neoplasm) made up of spindle cells (cells that are longer than they are wide).
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